Wiser about Scientific research

Sarcoidosis is a complex disease and a lot is still unknown. The diagnosis can be difficult. To diagnosis a patient with 100% certainty the presence of granulomas must be established in affected tissue. However, to acquire biopsy material might sometimes be associated with high mortality or morbidity. Furthermore, not all patient respond well to treatment. Especially in rare manifestations of sarcoidosis this is not well investigated. To improve our undertanding of the disease and to improve the diagnostic process and outcome we conduct scientific research.

Scientific research

Recent publications

Clinical features, treatment and outcome in neurosarcoidosis: systematic review and meta-analysis

Drs. D. Fritz, Prof. Dr. D. van de Beek, Dr. M.C. Brouwer In this article we collected information of all the large studies which describe patients diagnosed with neurosarcoidosis to give an adequate overview of clinical characteristics (symptoms), ancillary investigations, treatment and outcome in neurosarcoidosis. The conclusion is that the disease is diverse (a cameleon) and that despite the introduction of new third line treatment agents still one-third of patients remain stable, deteriorate or die.

An electronic nose discriminates exhaled breath of patients with untreated pulmonary sarcoidosis from controls

Dragonieri S, Brinkman P, Mouw E, Zwinderman AH, Carratú P, Resta O, Sterk PJ, Jonkers RE Because making the diagnosis sarcoidosis can be complex, it is important to improve the diagnostic process. In this article we describe an 'electronic nose' to check heter or not it can potentials identify sarcoidosis patients. They did this by comparing the exhaled air of untreated sarcoidosis patients with healthy controls. They did found that the exhaled air was different.

More recent publications

Research groups

Vasculitiscentrum AMCNeurosarcoïdose - Neuroinfecties Amsterdam