Wiser about Scientific research

Sarcoidosis is a complex disease and a lot is still unknown. The diagnosis can be difficult. To diagnosis a patient with 100% certainty the presence of granulomas must be established in affected tissue. However, to acquire biopsy material might sometimes be associated with high mortality or morbidity. Furthermore, not all patient respond well to treatment. Especially in rare manifestations of sarcoidosis this is not well investigated. To improve our undertanding of the disease and to improve the diagnostic process and outcome we conduct scientific research.

Scientific research

Recent publications

Endosonography vs conventional bronchoscopy for the diagnosis of sarcoidosis: the GRANULOMA randomized clinical trial

von Bartheld MB, Dekkers OM, Szlubowski A, Eberhardt R, Herth FJ, in 't Veen JC, de Jong YP, van der Heijden EH, Tournoy KG, Claussen M, van den Blink B, Shah PL, Zoumot Z, Clementsen P, Porsbjerg C, Mauad T, Bernardi FD, van Zwet EW, Rabe KF, Annema JT For the diagnosis of sarcoidosis, identifying granulomas in affected tissue is preferred. This is done by extracting lymph node tissue in the lungs via a biopsy. In this article the investigators evaluated what is the best way to perform the biopsy: with endosonography or with bronchoscopy (which is standard care). The article describes that endosonography is the best way to perform biopsy. Furthermore it describes what kind of complications might be expected.

Clinical features, treatment and outcome in neurosarcoidosis: systematic review and meta-analysis

Drs. D. Fritz, Prof. Dr. D. van de Beek, Dr. M.C. Brouwer In this article we collected information of all the large studies which describe patients diagnosed with neurosarcoidosis to give an adequate overview of clinical characteristics (symptoms), ancillary investigations, treatment and outcome in neurosarcoidosis. The conclusion is that the disease is diverse (a cameleon) and that despite the introduction of new third line treatment agents still one-third of patients remain stable, deteriorate or die.

More recent publications

Research groups

Neurosarcoïdose - Neuroinfecties AmsterdamVasculitiscentrum AMC