Wiser about Scientific research

Sarcoidosis is a complex disease and a lot is still unknown. The diagnosis can be difficult. To diagnosis a patient with 100% certainty the presence of granulomas must be established in affected tissue. However, to acquire biopsy material might sometimes be associated with high mortality or morbidity. Furthermore, not all patient respond well to treatment. Especially in rare manifestations of sarcoidosis this is not well investigated. To improve our undertanding of the disease and to improve the diagnostic process and outcome we conduct scientific research.

Scientific research

Recent publications

Clinical features, treatment and outcome in neurosarcoidosis: systematic review and meta-analysis

Drs. D. Fritz, Prof. Dr. D. van de Beek, Dr. M.C. Brouwer In this article we collected information of all the large studies which describe patients diagnosed with neurosarcoidosis to give an adequate overview of clinical characteristics (symptoms), ancillary investigations, treatment and outcome in neurosarcoidosis. The conclusion is that the disease is diverse (a cameleon) and that despite the introduction of new third line treatment agents still one-third of patients remain stable, deteriorate or die.

Neurosarcoidosis in a Tertiary Referral Center: A Cross-Sectional Cohort Study

Drs. S.E. Leonhard, Drs. D. Fritz, Dr. F. Eftimov, Dr. A.J. van der Kooi, Prof. dr. D. van de Beek, Dr. M.C. Brouwer In this research we have described the clinical characteristics, ancillary investigations, treatment and outcome of patients with neurosarcoidosis. The conclusion is that ancillary investigations have a low sensitivity and that half of the patients react favourable to first line treatment with prednisone.

More recent publications

Research groups

Neurosarcoïdose - Neuroinfecties AmsterdamVasculitiscentrum AMC