Wiser about Scientific research

Sarcoidosis is a complex disease and a lot is still unknown. The diagnosis can be difficult. To diagnosis a patient with 100% certainty the presence of granulomas must be established in affected tissue. However, to acquire biopsy material might sometimes be associated with high mortality or morbidity. Furthermore, not all patient respond well to treatment. Especially in rare manifestations of sarcoidosis this is not well investigated. To improve our undertanding of the disease and to improve the diagnostic process and outcome we conduct scientific research.

Scientific research

Recent publications

Neurosarcoidosis in a Tertiary Referral Center: A Cross-Sectional Cohort Study

Drs. S.E. Leonhard, Drs. D. Fritz, Dr. F. Eftimov, Dr. A.J. van der Kooi, Prof. dr. D. van de Beek, Dr. M.C. Brouwer In this research we have described the clinical characteristics, ancillary investigations, treatment and outcome of patients with neurosarcoidosis. The conclusion is that ancillary investigations have a low sensitivity and that half of the patients react favourable to first line treatment with prednisone.

Plasma chitotriosidase and CCL18 as surrogate markers for granulomatous macrophages in sarcoidosis

Boot RG, Hollak CE, Verhoek M, Alberts C, Jonkers RE, Aerts JM The diagnosis of sarcoidosis can be complex and therefore the diagnostic process must be improved. In this article we looked for markers in the blood that can have a role in the diagnosis but also in monitoring the disease activity. More specifically they investigated 'chitotriosidase' en 'CCL18'. These two markers show potential.

More recent publications

Research groups

Neurosarcoïdose - Neuroinfecties AmsterdamVasculitiscentrum AMC