Wiser about Scientific research

Sarcoidosis is a complex disease and much concerning this disease is still unknown. It can be difficult to diagnose patients. In some cases it is necessary to diagnose someone using biopsies, to determine the presence of granulomas under the microscope, with 100% certainty. However, sometimes this biopsy is considered to difficult or to dangerous. Think about obtaining brain- or nerve tissue in case of involvement of the nervous system (neurosarcoidosis) in some, but not all cases. Furthermore, not all patient respond wel to treatment. Especially in some rare manifestations of the disease this has not been investigated yet. To understand the disease better we are conducting scientific research of chronic inflammatory disorders, like sarcoidosis. We hope to collect more knowledge about this disease to ultimately improve patient care.

Scientific research

Recent publications

Clinical features, treatment and outcome in neurosarcoidosis: systematic review and meta-analysis

Drs. D. Fritz, Prof. Dr. D. van de Beek, Dr. M.C. Brouwer In this article we collected information of all the large studies which describe patients diagnosed with neurosarcoidosis to give an adequate overview of clinical characteristics (symptoms), ancillary investigations, treatment and outcome in neurosarcoidosis. The conclusion is that the disease is diverse (a cameleon) and that despite the introduction of new third line treatment agents still one-third of patients remain stable, deteriorate or die.

Plasma chitotriosidase and CCL18 as surrogate markers for granulomatous macrophages in sarcoidosis

Boot RG, Hollak CE, Verhoek M, Alberts C, Jonkers RE, Aerts JM The diagnosis of sarcoidosis can be complex and therefore the diagnostic process must be improved. In this article we looked for markers in the blood that can have a role in the diagnosis but also in monitoring the disease activity. More specifically they investigated 'chitotriosidase' en 'CCL18'. These two markers show potential.

More recent publications

Research groups

Neurosarcoïdose - Neuroinfecties AmsterdamVasculitiscentrum AMC